eprintid: 1031
rev_number: 10
eprint_status: archive
userid: 44
dir: disk0/00/00/10/31
datestamp: 2011-12-05 15:49:54
lastmod: 2013-03-12 14:57:38
status_changed: 2011-12-05 15:49:54
type: article
metadata_visibility: show
creators_name: Sopasakis, Pantelis
creators_name: Patrinos, Panagiotis
creators_name: Giannikou, Stefania
creators_name: Sarimveis, Haralambos
creators_id: pantelis.sopasakis@imtlucca.it
creators_id: panagiotis.patrinos@imtlucca.it
creators_id: 
creators_id: 
title: Physiologically based pharmacokinetic modeling and predictive control: an integrated approach for optimal drug administration
ispublished: pub
subjects: QA75
subjects: RS
subjects: TJ
divisions: CSA
full_text_status: none
keywords: Model Predictive Control; PBPK models; Drug administration
abstract: The barriers between systems engineering and medicine are slowly eroding as recently it has become evident that medicine has a lot to gain from systems technology. In particular, the drug administration problem can be cast as a control engineering problem, where the objective is to keep the drug concentration at certain organs in the body close to desired set-points. A number of constraints render the problem rather challenging. For example, hard constraints may be posed on drug concentration, because if it exceeds an upper limit, the effects of the drug are adverse and toxic.

In this paper we show that a popular method in control engineering can be used for determining the optimal drug administration. Specifically, the Model Predictive Control (MPC) technology can be adopted for taking optimal decisions regarding regulation of drug concentration in the human body, while posing constraints on both drug concentration and drug infusion rate.
date: 2011
publication: Computer Aided Chemical Engineering
volume: 29
publisher: Elsevier
pagerange: 1490-1494
id_number: doi:10.1016/B978-0-444-54298-4.50077-5
refereed: TRUE
issn: 1570-7946
book_title: 21st European Symposium on Computer Aided Process Engineering
official_url: http://dx.doi.org/10.1016/B978-0-444-54298-4.50077-5
citation:   Sopasakis, Pantelis and Patrinos, Panagiotis and Giannikou, Stefania and Sarimveis, Haralambos  Physiologically based pharmacokinetic modeling and predictive control: an integrated approach for optimal drug administration.  Computer Aided Chemical Engineering, 29.  pp. 1490-1494.  ISSN 1570-7946      (2011)