TY - JOUR A1 - Auconi, Pietro A1 - Caldarelli, Guido A1 - Scala, Antonio A1 - Ierardo, Gaetano A1 - Polimeni, Antonella SP - 189 EP - 197 VL - 14 PB - Wiley-Blackwell KW - class II and class III malocclusions; craniofacial topology; network analysis UR - http://dx.doi.org/10.1111/j.1601-6343.2011.01523.x IS - 4 ID - eprints1195 TI - A network approach to orthodontic diagnosis AV - none Y1 - 2011/10// SN - 1601-6335 JF - Orthodontics and Craniofacial Research N2 - Background??? Network analysis, a recent advancement in complexity science, enables understanding of the properties of complex biological processes characterized by the interaction, adaptive regulation, and coordination of a large number of participating components. Objective??? We applied network analysis to orthodontics to detect and visualize the most interconnected clinical, radiographic, and functional data pertaining to the orofacial system. Materials and Methods??? The sample consisted of 104 individuals from 7 to 13 years of age in the mixed dentition phase without previous orthodontic intervention. The subjects were divided according to skeletal class; their clinical, radiographic, and functional features were represented as vertices (nodes) and links (edges) connecting them. Results??? Class II subjects exhibited few highly connected orthodontic features (hubs), while Class III patients showed a more compact network structure characterized by strong co-occurrence of normal and abnormal clinical, functional, and radiological features. Restricting our analysis to the highest correlations, we identified critical peculiarities of Class II and Class III malocclusions. Conclusions??? The topology of the dentofacial system obtained by network analysis could allow orthodontists to visually evaluate and anticipate the co-occurrence of auxological anomalies during individual craniofacial growth and possibly localize reactive sites for a therapeutic approach to malocclusion. ER -