%X Research on metamodel-based optimization has received considerably increasing interest in recent years, and has found successful applications in solving computationally expensive problems. The joint use of computer simulation experiments and metamodels introduces a source of uncertainty that we refer to as metamodel variability. To analyze and quantify this variability, we apply bootstrapping to residuals derived as prediction errors computed from cross-validation. The proposed method can be used with different types of metamodels, especially when limited knowledge on parameters? distribution is available or when a limited computational budget is allowed. Our preliminary experiments based on the robust version of the EOQ model show encouraging results. %L eprints1444 %D 2012 %A Gabriella Dellino %A Carlo Meloni %C Berlin, Germany %B WSC '12 Proceedings of the Winter Simulation Conference %T Metamodel variability analysis combining bootstrapping and validation techniques %I ACM %O Article No.: 334