eprintid: 1463
rev_number: 7
eprint_status: archive
userid: 44
dir: disk0/00/00/14/63
datestamp: 2013-01-24 09:27:55
lastmod: 2013-03-12 14:57:38
status_changed: 2013-01-24 09:27:55
type: article
metadata_visibility: show
creators_name: Sopasakis, Pantelis
creators_name: Sarimveis, Haralambos
creators_id: pantelis.sopasakis@imtlucca.it
creators_id: 
title: An integer programming approach for optimal drug dose computation
ispublished: pub
subjects: QA75
subjects: RM
divisions: CSA
full_text_status: none
keywords: Optimal drug dosing; FIR model; Pharmacokinetics; Integer programming
abstract: In this paper, we study the problem of determining the optimal drug administration strategy when only a finite number of different dosages are available, a lower bound is posed on the time intervals between two consecutive doses, and drug concentrations should not exceed the toxic concentration levels. The presence of only binary variables leads to the adoption of an integer programming (IP) scheme for the formulation and solution of the drug dose optimal control problem. The proposed method is extended to account for the stochastic formulation of the optimal control problem, so that it can be used in practical applications where large populations of patients are to be treated. A Finite Impulse Response (FIR) model derived from experimental pharmacokinetic data is employed to correlate the administered drug dose with the concentration–time profiles of the drug in the compartments (organs) of the body.
date: 2012-12
date_type: published
publication: Computer Methods and Programs in Biomedicine
volume: 108
number: 3
publisher: Elsevier
pagerange: 1022-1035
id_number: 10.1016/j.cmpb.2012.06.008
refereed: TRUE
issn: 0169-2607
official_url: http://dx.doi.org/10.1016/j.cmpb.2012.06.008
citation:   Sopasakis, Pantelis and Sarimveis, Haralambos  An integer programming approach for optimal drug dose computation.  Computer Methods and Programs in Biomedicine, 108 (3).  pp. 1022-1035.  ISSN 0169-2607      (2012)