eprintid: 1468
rev_number: 13
eprint_status: archive
userid: 44
dir: disk0/00/00/14/68
datestamp: 2013-01-24 15:10:05
lastmod: 2013-03-12 14:57:38
status_changed: 2013-01-24 15:10:05
type: book_section
metadata_visibility: show
creators_name: Sarimveis, Haralambos
creators_name: Sopasakis, Pantelis
creators_name: Afantitis, Antreas
creators_name: Melagraki, Georgia
creators_id: 
creators_id: pantelis.sopasakis@imtlucca.it
creators_id: 
creators_id: 
title: A Model Predictive Control Approach for Optimal Drug Administration
ispublished: pub
subjects: QA75
subjects: RM
subjects: TP
divisions: CSA
full_text_status: none
pres_type: paper
note: Proceedings of the ICheaP-9 - The 9th international conference on Chemical and Process Engineering, held in Rome, Italy, 10-13 May 2009
abstract: The barriers between systems engineering and medicine are slowly eroding as recently it has become evident that medicine has a lot to gain by systems technology. In particular, the drug administration problem be cast as a control engineering problem, where the objective is to keep the drug concentration at certain organs in the body close to desired set-points. A number of constraints render the problem rather challenging. For example, hard constraints may be posed on the drug concentration in blood, because a higher than a certain limit concentration may render the drug effects adverse and toxic. In this paper we show that a popular method for tackling chemical engineering control problems can be used for determining  the optimal drug administration. Specifically, the Model Predictive Control (MPC) technology is used for taking optimal decisions regarding of drug concentration in the human body, while incorporating constraints on both drug concentration and drug infusion rate.  
date: 2009
date_type: published
volume: 17
publisher: AIDIC
pagerange: 1311-1316
pages: 6
id_number: 10.3303/CET0917219
refereed: TRUE
isbn: 978-88-95608-01-3
book_title: Chemical Engineering Transactions, Series
official_url: http://www.aidic.it/cet/09/17/219.pdf
citation:   Sarimveis, Haralambos and Sopasakis, Pantelis and Afantitis, Antreas and Melagraki, Georgia  A Model Predictive Control Approach for Optimal Drug Administration.   In:  Chemical Engineering Transactions, Series.   AIDIC, pp. 1311-1316.  ISBN 978-88-95608-01-3      (2009)