<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Detecting Myocardial Ischemia at Rest With Cardiac Phase-Resolved Blood Oxygen Level-Dependent Cardiovascular Magnetic Resonance"^^ . "Background: Fast, noninvasive identification of ischemic territories at rest (prior to tissue-specific changes) and assessment of functional status can be valuable in the management of severe coronary artery disease. This study investigated the utility of cardiac phase-resolved Blood-Oxygen-Level-Dependent (CP-BOLD) CMR in detecting myocardial ischemia at rest secondary to severe coronary artery stenosis.\r\n\r\nMethods and Results: CP-BOLD, standard-cine, and T2-weighted images were acquired in canines (n=11) at baseline and within 20 minutes of ischemia induction (severe LAD stenosis) at rest. Following 3-hours of ischemia, LAD stenosis was removed and T2-weighted and late-gadolinium-enhancement (LGE) images were acquired. From standard-cine and CP-BOLD images, End-Systolic (ES) and End-Diastolic (ED) myocardium were segmented. Affected and remote sections of the myocardium were identified from post-reperfusion LGE images. S/D, quotient of mean ES and ED signal intensities (on CP-BOLD and standard-cine), was computed for affected and remote segments at baseline and ischemia. Ejection fraction (EF) and segmental wall-thickening (sWT) were derived from CP-BOLD images at baseline and ischemia. On CP-BOLD images: S/D was greater than 1 (remote and affected territories) at baseline; S/D was diminished only in affected territories during ischemia and the findings were statistically significant (ANOVA, post-hoc p<0.01). The dependence of S/D on ischemia was not observed in standard-cine images. Computer simulations confirmed the experimental findings. ROC analysis showed that S/D identifies affected regions with similar performance (AUC:0.87) as EF (AUC:0.89) and sWT (AUC:0.75).\r\n\r\nConclusions: Preclinical studies and computer simulations showed that CP-BOLD CMR could be useful in detecting myocardial ischemia at rest. Patient studies are needed for clinical translation. "^^ . "2013" . "6" . "2" . . "American Heart Association"^^ . . . "Circulation: Cardiovascular Imaging"^^ . . . "19419651" . . . . . . . . . . . . . . . . . . . "Richard"^^ . "Tang"^^ . "Richard Tang"^^ . . "Debiao"^^ . "Li"^^ . "Debiao Li"^^ . . "Rohan"^^ . "Dharmakumar"^^ . "Rohan Dharmakumar"^^ . . "Sotirios A."^^ . "Tsaftaris"^^ . "Sotirios A. Tsaftaris"^^ . . "Xiangzhi "^^ . "Zhou"^^ . "Xiangzhi Zhou"^^ . . . . . "HTML Summary of #1916 \n\nDetecting Myocardial Ischemia at Rest With Cardiac Phase-Resolved Blood Oxygen Level-Dependent Cardiovascular Magnetic Resonance\n\n" . "text/html" . . . "QA75 Electronic computers. Computer science"@en . . . "RC Internal medicine"@en . .