relation: http://eprints.imtlucca.it/2425/
title: Multicontrast MRI quantification of focal inflammation and degeneration in multiple sclerosis
creator: Bonnier, Guillaume
creator: Roche, Alexis
creator: Romascano, David
creator: Simioni, Samanta
creator: Meskaldji, Djalel-Eddine
creator: Rotzinger, David
creator: Lin, Ying-Chia
creator: Menegaz, Gloria
creator: Schluep, Myriam
creator: Du Pasquier, Renaud
creator: Sumpf, Tilman Johannes
creator: Frahm, Jens
creator: Thiran, Jean-Philippe
creator: Krueger, Gunnar
creator: Granziera, Cristina
subject: QA75 Electronic computers. Computer science
subject: RC Internal medicine
description: Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based lesion pathology in cognition and disability. Methods. 36 relapsing-remitting MS subjects and 18 healthy controls underwent neurological, cognitive, behavioural examinations and 3 T MRI including (i) fluid attenuated inversion recovery, double inversion recovery, and magnetization-prepared gradient echo for lesion count; (ii) T1, T2, and T2* relaxometry and magnetisation transfer imaging for lesion tissue characterization. Lesions were classified according to the extent of inflammation/neurodegeneration. A generalized linear model assessed the contribution of lesion groups to clinical performances. Results. Four lesion groups were identified and characterized by (1) absence of significant alterations, (2) prevalent inflammation, (3) concomitant inflammation and microdegeneration, and (4) prevalent tissue loss. Groups 1, 3, 4 correlated with general disability (Adj-; ), executive function (Adj-; ), verbal memory (Adj-; ), and attention (Adj-; ). Conclusion. Multicontrast MRI provides a new approach to infer in vivo histopathology of plaques. Our results support evidence that neurodegeneration is the major determinant of patients’ disability and cognitive dysfunction
publisher: Hindawi Publishing Corporation
date: 2014-10
type: Article
type: PeerReviewed
format: application/pdf
language: en
rights: cc_by_nd
identifier: http://eprints.imtlucca.it/2425/1/BioMed_res_int_Lin_2014.pdf
identifier:   Bonnier, Guillaume and Roche, Alexis and Romascano, David and Simioni, Samanta and Meskaldji, Djalel-Eddine and Rotzinger, David and Lin, Ying-Chia and Menegaz, Gloria and Schluep, Myriam and Du Pasquier, Renaud and Sumpf, Tilman Johannes and Frahm, Jens and Thiran, Jean-Philippe and Krueger, Gunnar and Granziera, Cristina  Multicontrast MRI quantification of focal inflammation and degeneration in multiple sclerosis.  BioMed Research International, 25 (569123).  pp. 1-10.  ISSN 2314-6133      (2014)  
relation: http://www.hindawi.com/journals/bmri/aa/569123/
relation: 10.1155/2015/569123