relation: http://eprints.imtlucca.it/2873/
title: Morphometric Changes of the Corpus Callosum in Congenital Blindness
creator: Tomaiuolo, Francesco
creator: Campana, Serena
creator: Collins, D. Louis
creator: Fonov, Vladimir S.
creator: Ricciardi, Emiliano
creator: Sartori, Giuseppe
creator: Pietrini, Pietro
creator: Kupers, Ron
creator: Ptito, Maurice
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: We examined the effects of visual deprivation at birth on the development of the corpus callosum in a large group of congenitally blind individuals. We acquired high-resolution T1-weighted MRI scans in 28 congenitally blind and 28 normal sighted subjects matched for age and gender. There was no overall group effect of visual deprivation on the total surface area of the corpus callosum. However, subdividing the corpus callosum into five subdivisions revealed significant regional changes in its three most posterior parts. Compared to the sighted controls, congenitally blind individuals showed a 12 reduction in the splenium, and a 20 increase in the isthmus and the posterior part of the body. A shape analysis further revealed that the bending angle of the corpus callosum was more convex in congenitally blind compared to the sighted control subjects. The observed morphometric changes in the corpus callosum are in line with the well-described cross-modal functional and structural neuroplastic changes in congenital blindness.
publisher: Public Library of Science
date: 2014
type: Article
type: PeerReviewed
format: application/pdf
language: en
rights: cc_by_nc
identifier: http://eprints.imtlucca.it/2873/1/journal.pone.0107871.pdf
identifier:   Tomaiuolo, Francesco and Campana, Serena and Collins, D. Louis and Fonov, Vladimir S. and Ricciardi, Emiliano and Sartori, Giuseppe and Pietrini, Pietro and Kupers, Ron and Ptito, Maurice  Morphometric Changes of the Corpus Callosum in Congenital Blindness.  PloS One, 9.  e107871.  ISSN 1932-6203      (2014)  
relation: http://dx.doi.org/10.1371%2Fjournal.pone.0107871
relation: 10.1371%2Fjournal.pone.0107871