TY  - JOUR
VL  - 9
ID  - eprints2873
PB  - Public Library of Science
SN  - 1932-6203
A1  - Tomaiuolo, Francesco
A1  - Campana, Serena
A1  - Collins, D. Louis
A1  - Fonov, Vladimir S.
A1  - Ricciardi, Emiliano
A1  - Sartori, Giuseppe
A1  - Pietrini, Pietro
A1  - Kupers, Ron
A1  - Ptito, Maurice
N2  - We examined the effects of visual deprivation at birth on the development of the corpus callosum in a large group of congenitally blind individuals. We acquired high-resolution T1-weighted MRI scans in 28 congenitally blind and 28 normal sighted subjects matched for age and gender. There was no overall group effect of visual deprivation on the total surface area of the corpus callosum. However, subdividing the corpus callosum into five subdivisions revealed significant regional changes in its three most posterior parts. Compared to the sighted controls, congenitally blind individuals showed a 12 reduction in the splenium, and a 20 increase in the isthmus and the posterior part of the body. A shape analysis further revealed that the bending angle of the corpus callosum was more convex in congenitally blind compared to the sighted control subjects. The observed morphometric changes in the corpus callosum are in line with the well-described cross-modal functional and structural neuroplastic changes in congenital blindness.
Y1  - 2014///
KW  - Corpus callosum
KW  -  Blindness
KW  -  Magnetic resonance imaging
KW  -  Retinopathy of prematurity
KW  -  Preterm birth
KW  -  Vision
TI  - Morphometric Changes of the Corpus Callosum in Congenital Blindness
AV  - public
JF  - PloS One
UR  - http://dx.doi.org/10.1371%2Fjournal.pone.0107871
ER  -