eprintid: 2873
rev_number: 8
eprint_status: archive
userid: 69
dir: disk0/00/00/28/73
datestamp: 2015-11-10 11:47:36
lastmod: 2016-09-13 09:46:12
status_changed: 2015-11-10 11:47:36
type: article
metadata_visibility: show
creators_name: Tomaiuolo, Francesco
creators_name: Campana, Serena
creators_name: Collins, D. Louis
creators_name: Fonov, Vladimir S.
creators_name: Ricciardi, Emiliano
creators_name: Sartori, Giuseppe
creators_name: Pietrini, Pietro
creators_name: Kupers, Ron
creators_name: Ptito, Maurice
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: emiliano.ricciardi@imtlucca.it
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
title: Morphometric Changes of the Corpus Callosum in Congenital Blindness
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: public
keywords: Corpus callosum, Blindness, Magnetic resonance imaging, Retinopathy of prematurity, Preterm birth, Vision
abstract: We examined the effects of visual deprivation at birth on the development of the corpus callosum in a large group of congenitally blind individuals. We acquired high-resolution T1-weighted MRI scans in 28 congenitally blind and 28 normal sighted subjects matched for age and gender. There was no overall group effect of visual deprivation on the total surface area of the corpus callosum. However, subdividing the corpus callosum into five subdivisions revealed significant regional changes in its three most posterior parts. Compared to the sighted controls, congenitally blind individuals showed a 12 reduction in the splenium, and a 20 increase in the isthmus and the posterior part of the body. A shape analysis further revealed that the bending angle of the corpus callosum was more convex in congenitally blind compared to the sighted control subjects. The observed morphometric changes in the corpus callosum are in line with the well-described cross-modal functional and structural neuroplastic changes in congenital blindness.
date: 2014
date_type: published
publication: PloS One
volume: 9
publisher: Public Library of Science
pagerange: e107871
id_number: 10.1371%2Fjournal.pone.0107871
refereed: TRUE
issn: 1932-6203
official_url: http://dx.doi.org/10.1371%2Fjournal.pone.0107871
citation:   Tomaiuolo, Francesco and Campana, Serena and Collins, D. Louis and Fonov, Vladimir S. and Ricciardi, Emiliano and Sartori, Giuseppe and Pietrini, Pietro and Kupers, Ron and Ptito, Maurice  Morphometric Changes of the Corpus Callosum in Congenital Blindness.  PloS One, 9.  e107871.  ISSN 1932-6203      (2014)  
document_url: http://eprints.imtlucca.it/2873/1/journal.pone.0107871.pdf