TY  - JOUR
AV  - none
ID  - eprints2874
TI  - Cholinergic enhancement reduces functional connectivity and BOLD variability in visual extrastriate cortex during selective attention
UR  - http://www.sciencedirect.com/science/article/pii/S0028390812003322
N2  - Enhancing cholinergic function improves performance on various cognitive tasks and alters neural responses in task specific brain regions. We have hypothesized that the changes in neural activity observed during increased cholinergic function reflect an increase in neural efficiency that leads to improved task performance. The current study tested this hypothesis by assessing neural efficiency based on cholinergically-mediated effects on regional brain connectivity and BOLD signal variability. Nine subjects participated in a double-blind, placebo-controlled crossover fMRI study. Following an infusion of physostigmine (1 mg/h) or placebo, echo-planar imaging (EPI) was conducted as participants performed a selective attention task. During the task, two images comprised of superimposed pictures of faces and houses were presented. Subjects were instructed periodically to shift their attention from one stimulus component to the other and to perform a matching task using hand held response buttons. A control condition included phase-scrambled images of superimposed faces and houses that were presented in the same temporal and spatial manner as the attention task; participants were instructed to perform a matching task. Cholinergic enhancement improved performance during the selective attention task, with no change during the control task. Functional connectivity analyses showed that the strength of connectivity between ventral visual processing areas and task-related occipital, parietal and prefrontal regions reduced significantly during cholinergic enhancement, exclusively during the selective attention task. Physostigmine administration also reduced BOLD signal temporal variability relative to placebo throughout temporal and occipital visual processing areas, again during the selective attention task only. Together with the observed behavioral improvement, the decreases in connectivity strength throughout task-relevant regions and {BOLD} variability within stimulus processing regions support the hypothesis that cholinergic augmentation results in enhanced neural efficiency. This article is part of a Special Issue entitled ?Cognitive Enhancers?.
KW  - Functional magnetic resonance imaging
JF  - Neuropharmacology
SN  - 0028-3908
PB  - Elsevier
VL  - 64
EP  -  313
Y1  - 2013/01//
SP  - 305 
A1  - Ricciardi, Emiliano
A1  - Handjaras, Giacomo
A1  - Bernardi, Giulio
A1  - Pietrini, Pietro
A1  - Furey, Maura L.
ER  -