eprintid: 3016
rev_number: 7
eprint_status: archive
userid: 69
dir: disk0/00/00/30/16
datestamp: 2016-01-19 15:25:22
lastmod: 2016-04-06 07:36:06
status_changed: 2016-01-19 15:25:22
type: conference_item
metadata_visibility: show
creators_name: Boschetto, Davide
creators_name: Di Prima, P.
creators_name: Castellaro, M.
creators_name: Bertoldo, A.
creators_name: Grisan, Enrico
creators_id: davide.boschetto@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: Baseline constrained reconstruction of DSC-MRI tracer kinetics from sparse fourier data
ispublished: pub
subjects: QA75
subjects: T1
divisions: CSA
full_text_status: none
pres_type: paper
keywords: Fourier analysis, Biomedical MRI, Brain, Compressed sensing, Haemorheology, Image reconstruction, Image resolution, Medical image processing.
abstract: In order to assess brain perfusion, one of the available methods is the estimation of parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) from Dynamic Susceptibility Contrast MRI (DSC-MRI). This estimation requires both high temporal and spatial resolution to capture the rapid tracer kinetic and detect small impairments and reliably discriminate boundaries. With this in mind, we propose a compressed sensing approach to decrease the acquisition time without sacrificing the reconstruction, especially in the region affected by the tracer. Within the framework of a TV-L1-L2 minimization for solving the reconstruction from partial Fourier data, we introduce a novel baseline-constraining term weighting the difference of the reconstructed volume from the baseline in all regions where no perfusion is apparent. We show that the proposed reconstruction scheme is able to provide accurate estimation of the tracer kinetics (the necessary step for estimating CBF, CBV and MTT) in the volume even at high acceleration (x16), with a RMSE of 11, a third of what achievable without the baseline constraint.
date: 2014-04
date_type: published
publisher: IEEE
pagerange: 321-324
event_title: 2014 IEEE International Symposium on Biomedical Imaging
event_location: Beijing
event_dates: April 29-May 2, 2014
event_type: conference
id_number: 10.1109/ISBI.2014.6867873
refereed: TRUE
isbn: 978-1-4673-1961-4
book_title: 2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI)
official_url: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6867873
citation:   Boschetto, Davide and Di Prima, P. and Castellaro, M. and Bertoldo, A. and Grisan, Enrico  Baseline constrained reconstruction of DSC-MRI tracer kinetics from sparse fourier data.  In: 2014 IEEE International Symposium on Biomedical Imaging, April 29-May 2, 2014, Beijing pp. 321-324.  ISBN 978-1-4673-1961-4.      (2014)