eprintid: 3090
rev_number: 6
eprint_status: archive
userid: 69
dir: disk0/00/00/30/90
datestamp: 2016-02-19 12:42:01
lastmod: 2016-09-13 10:00:28
status_changed: 2016-02-19 12:42:01
type: article
metadata_visibility: show
creators_name: Gentili, Claudio
creators_name: Gobbini, Maria Ida
creators_name: Ricciardi, Emiliano
creators_name: Vanello, Nicola
creators_name: Pietrini, Pietro
creators_name: Haxby, James V.
creators_name: Guazzelli, Mario
creators_id: 
creators_id: 
creators_id: emiliano.ricciardi@imtlucca.it
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
title: Differential modulation of neural activity throughout the distributed neural system for face perception in patients with Social Phobia and healthy subjects
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
keywords: Superior temporal sulcus; Social phobia; Neural system for face perception
abstract: Social Phobia (SP) is a marked and persistent fear of social or performance situations in which the person is exposed to unfamiliar people or to possible scrutiny by others. Faces of others are perceived as threatening by social phobic patients (SPP). To investigate how face processing is altered in the distributed neural system for face perception in Social Phobia, we designed an event-related fMRI study in which Healthy Controls (HC) and {SPP} were presented with angry, fearful, disgusted, happy and neutral faces and scrambled pictures (visual baseline). As compared to HC, {SPP} showed increased neural activity not only in regions involved in emotional processing including left amygdala and insula, as expected from previous reports, but also in the bilateral superior temporal sulcus (STS), a part of the core system for face perception that is involved in the evaluation of expression and personal traits. In addition {SPP} showed a significantly weaker activation in the left fusiform gyrus, left dorsolateral prefrontal cortex, and bilateral intraparietal sulcus as compared to HC. These effects were found not only in response to emotional faces but also to neutral faces as compared to scrambled pictures. Thus, {SPP} showed enhanced activity in brain areas related to processing of information about emotional expression and personality traits. In contrast, brain activity was decreased in areas for attention and for processing other information from the face, perhaps as a result of a feeling of wariness. These results indicate a differential modulation of neural activity throughout the different parts of the distributed neural system for face perception in {SPP} as compared to HC.
date: 2008
date_type: published
publication: Brain Research Bulletin
volume: 77
number: 5
publisher: Elsevier
pagerange: 286 - 292
id_number: 10.1016/j.brainresbull.2008.08.003
refereed: TRUE
issn: 0361-9230
official_url: http://www.sciencedirect.com/science/article/pii/S0361923008002724
citation:   Gentili, Claudio and Gobbini, Maria Ida and Ricciardi, Emiliano and Vanello, Nicola and Pietrini, Pietro and Haxby, James V. and Guazzelli, Mario  Differential modulation of neural activity throughout the distributed neural system for face perception in patients with Social Phobia and healthy subjects.  Brain Research Bulletin, 77 (5).  286 - 292.  ISSN 0361-9230      (2008)