%0 Journal Article
%@ 0047-6374
%A Straniero, Sara
%A Cavallini, Gabriella
%A Donati, Alessio
%A Metelli, Maria Rita
%A Tamburini, Ilaria
%A Pietrini, Pietro
%A Bergamini, Ettore
%D 2008
%F eprints:3091
%I Elsevier
%J Mechanisms of Ageing and Development
%K Ageing; Cholesterol; Triglycerides; Dietary PUFA; Rat
%N 12
%P 759 - 762
%T Deficiency and supplementation of {PUFA} in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels
%U http://eprints.imtlucca.it/3091/
%V 129
%X Levels of plasma cholesterol, particularly {LDL} cholesterol, increase with increasing age in humans and rodents. Feeding a fish oil-rich diet may exert hypocholesterolemic effects. The aim of this work was to examine the effects of a life-long administration of a PUFA-enriched diet and of a PUFA-deficient diet in male Sprague–Dawley rats on the age-associated increases in plasma cholesterol and triglycerides. Diet had small effects on body-weight, and had dramatic effects on liver phospholipids-fatty acids. Surprisingly, both diets counteracted the age-associated changes in plasma cholesterol and triglycerides similarly and benefits were already visible in adult rats.