TY  - JOUR
EP  -  762
PB  - Elsevier
VL  - 129
SP  - 759 
A1  - Straniero, Sara
A1  - Cavallini, Gabriella
A1  - Donati, Alessio
A1  - Metelli, Maria Rita
A1  - Tamburini, Ilaria
A1  - Pietrini, Pietro
A1  - Bergamini, Ettore
AV  - none
TI  - Deficiency and supplementation of {PUFA} in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels
ID  - eprints3091
IS  - 12
UR  - http://www.sciencedirect.com/science/article/pii/S0047637408001802
KW  - Ageing; Cholesterol; Triglycerides; Dietary PUFA; Rat
SN  - 0047-6374
Y1  - 2008///
N2  - Levels of plasma cholesterol, particularly {LDL} cholesterol, increase with increasing age in humans and rodents. Feeding a fish oil-rich diet may exert hypocholesterolemic effects. The aim of this work was to examine the effects of a life-long administration of a PUFA-enriched diet and of a PUFA-deficient diet in male Sprague?Dawley rats on the age-associated increases in plasma cholesterol and triglycerides. Diet had small effects on body-weight, and had dramatic effects on liver phospholipids-fatty acids. Surprisingly, both diets counteracted the age-associated changes in plasma cholesterol and triglycerides similarly and benefits were already visible in adult rats.
JF  - Mechanisms of Ageing and Development
ER  -