%J Mechanisms of Ageing and Development
%P 759 - 762
%T Deficiency and supplementation of {PUFA} in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels
%R 10.1016/j.mad.2008.09.009
%X Levels of plasma cholesterol, particularly {LDL} cholesterol, increase with increasing age in humans and rodents. Feeding a fish oil-rich diet may exert hypocholesterolemic effects. The aim of this work was to examine the effects of a life-long administration of a PUFA-enriched diet and of a PUFA-deficient diet in male Sprague?Dawley rats on the age-associated increases in plasma cholesterol and triglycerides. Diet had small effects on body-weight, and had dramatic effects on liver phospholipids-fatty acids. Surprisingly, both diets counteracted the age-associated changes in plasma cholesterol and triglycerides similarly and benefits were already visible in adult rats.
%L eprints3091
%K Ageing; Cholesterol; Triglycerides; Dietary PUFA; Rat
%I Elsevier
%A Sara Straniero
%A Gabriella Cavallini
%A Alessio Donati
%A Maria Rita Metelli
%A Ilaria Tamburini
%A Pietro Pietrini
%A Ettore Bergamini
%D 2008
%N 12
%V 129