eprintid: 3091
rev_number: 6
eprint_status: archive
userid: 69
dir: disk0/00/00/30/91
datestamp: 2016-02-19 12:45:31
lastmod: 2016-02-19 12:45:31
status_changed: 2016-02-19 12:45:31
type: article
metadata_visibility: show
creators_name: Straniero, Sara
creators_name: Cavallini, Gabriella
creators_name: Donati, Alessio
creators_name: Metelli, Maria Rita
creators_name: Tamburini, Ilaria
creators_name: Pietrini, Pietro
creators_name: Bergamini, Ettore
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
title: Deficiency and supplementation of {PUFA} in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels
ispublished: pub
subjects: QH301
subjects: QP
divisions: CSA
full_text_status: none
keywords: Ageing; Cholesterol; Triglycerides; Dietary PUFA; Rat
abstract: Levels of plasma cholesterol, particularly {LDL} cholesterol, increase with increasing age in humans and rodents. Feeding a fish oil-rich diet may exert hypocholesterolemic effects. The aim of this work was to examine the effects of a life-long administration of a PUFA-enriched diet and of a PUFA-deficient diet in male Sprague–Dawley rats on the age-associated increases in plasma cholesterol and triglycerides. Diet had small effects on body-weight, and had dramatic effects on liver phospholipids-fatty acids. Surprisingly, both diets counteracted the age-associated changes in plasma cholesterol and triglycerides similarly and benefits were already visible in adult rats.
date: 2008
date_type: published
publication: Mechanisms of Ageing and Development
volume: 129
number: 12
publisher: Elsevier
pagerange: 759 - 762
id_number: 10.1016/j.mad.2008.09.009
refereed: TRUE
issn: 0047-6374
official_url: http://www.sciencedirect.com/science/article/pii/S0047637408001802
citation:   Straniero, Sara and Cavallini, Gabriella and Donati, Alessio and Metelli, Maria Rita and Tamburini, Ilaria and Pietrini, Pietro and Bergamini, Ettore  Deficiency and supplementation of {PUFA} in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels.  Mechanisms of Ageing and Development, 129 (12).  759 - 762.  ISSN 0047-6374      (2008)