relation: http://eprints.imtlucca.it/3243/
title: A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics
creator: Gagliardi, Mariacristina
creator: Bertero, Alice
creator: Bardi, Giuseppe
creator: Bifone, Angelo
subject: QD Chemistry
subject: TA Engineering (General). Civil engineering (General)
subject: TP Chemical technology
description: Abstract This paper reports the synthesis and the physicochemical, functional and biological characterisations of nanocarriers made of a novel di-block biodegradable poly(ether-ester) copolymer. This material presents tunable, fast biodegradation rates, but its products are less acidic than those of other biosorbable polymers like PLGA, thus presenting a better biocompatibility profile and the possibility to carry pH-sensitive payloads. A method for the production of monodisperse and spherical nanoparticles is proposed; drug delivery kinetics and blood protein adsorption were measured to evaluate the functional properties of these nanoparticles as drug carriers. The copolymer was labelled with a fluorescent dye for internalisation tests, and rhodamine B was used as a model cargo to study transport and release inside cultured cells. Biological tests demonstrated good cytocompatibility, significant cell internalisation and the possibility to vehiculate non-cell penetrating moieties into endothelial cells. Taken together, these results support the potential use of this nanoparticulate system for systemic administration of drugs.
publisher: Elsevier
date: 2016
type: Article
type: PeerReviewed
identifier:   Gagliardi, Mariacristina and Bertero, Alice and Bardi, Giuseppe and Bifone, Angelo  A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics.  Materials Science and Engineering: C, 59.  488 - 499.  ISSN 0928-4931      (2016)  
relation: http://www.sciencedirect.com/science/article/pii/S0928493115304847
relation: 10.1016/j.msec.2015.10.054