<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics"^^ . "Abstract This paper reports the synthesis and the physicochemical, functional and biological characterisations of nanocarriers made of a novel di-block biodegradable poly(ether-ester) copolymer. This material presents tunable, fast biodegradation rates, but its products are less acidic than those of other biosorbable polymers like PLGA, thus presenting a better biocompatibility profile and the possibility to carry pH-sensitive payloads. A method for the production of monodisperse and spherical nanoparticles is proposed; drug delivery kinetics and blood protein adsorption were measured to evaluate the functional properties of these nanoparticles as drug carriers. The copolymer was labelled with a fluorescent dye for internalisation tests, and rhodamine B was used as a model cargo to study transport and release inside cultured cells. Biological tests demonstrated good cytocompatibility, significant cell internalisation and the possibility to vehiculate non-cell penetrating moieties into endothelial cells. Taken together, these results support the potential use of this nanoparticulate system for systemic administration of drugs."^^ . "2016" . "59" . . "Elsevier"^^ . . . "Materials Science and Engineering: C"^^ . . . "09284931" . . . . . . . . . . . . . . . . "Giuseppe"^^ . "Bardi"^^ . "Giuseppe Bardi"^^ . . "Mariacristina"^^ . "Gagliardi"^^ . "Mariacristina Gagliardi"^^ . . "Angelo"^^ . "Bifone"^^ . "Angelo Bifone"^^ . . "Alice"^^ . "Bertero"^^ . "Alice Bertero"^^ . . . . . "HTML Summary of #3243 \n\nA poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics\n\n" . "text/html" . . . "QD Chemistry"@en . . . "TA Engineering (General). Civil engineering (General)"@en . . . "TP Chemical technology"@en . .