TY  - JOUR
EP  -  499
A1  - Gagliardi, Mariacristina
A1  - Bertero, Alice
A1  - Bardi, Giuseppe
A1  - Bifone, Angelo
UR  - http://www.sciencedirect.com/science/article/pii/S0928493115304847
PB  - Elsevier
TI  - A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics
VL  - 59
Y1  - 2016///
JF  - Materials Science and Engineering: C
ID  - eprints3243
N2  - Abstract This paper reports the synthesis and the physicochemical, functional and biological characterisations of nanocarriers made of a novel di-block biodegradable poly(ether-ester) copolymer. This material presents tunable, fast biodegradation rates, but its products are less acidic than those of other biosorbable polymers like PLGA, thus presenting a better biocompatibility profile and the possibility to carry pH-sensitive payloads. A method for the production of monodisperse and spherical nanoparticles is proposed; drug delivery kinetics and blood protein adsorption were measured to evaluate the functional properties of these nanoparticles as drug carriers. The copolymer was labelled with a fluorescent dye for internalisation tests, and rhodamine B was used as a model cargo to study transport and release inside cultured cells. Biological tests demonstrated good cytocompatibility, significant cell internalisation and the possibility to vehiculate non-cell penetrating moieties into endothelial cells. Taken together, these results support the potential use of this nanoparticulate system for systemic administration of drugs.
SP  - 488 
KW  - Biodegradable nanoparticles; Drug delivery; Biodegradation; Biocompatibility; Metoxy polyethyleneglycol-block-poly(?-caprolactone-co-4-hydroxyvalerolactone)
SN  - 0928-4931
AV  - none
ER  -