%T A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics
%P 488 - 499
%I Elsevier
%V 59
%D 2016
%L eprints3243
%X Abstract This paper reports the synthesis and the physicochemical, functional and biological characterisations of nanocarriers made of a novel di-block biodegradable poly(ether-ester) copolymer. This material presents tunable, fast biodegradation rates, but its products are less acidic than those of other biosorbable polymers like PLGA, thus presenting a better biocompatibility profile and the possibility to carry pH-sensitive payloads. A method for the production of monodisperse and spherical nanoparticles is proposed; drug delivery kinetics and blood protein adsorption were measured to evaluate the functional properties of these nanoparticles as drug carriers. The copolymer was labelled with a fluorescent dye for internalisation tests, and rhodamine B was used as a model cargo to study transport and release inside cultured cells. Biological tests demonstrated good cytocompatibility, significant cell internalisation and the possibility to vehiculate non-cell penetrating moieties into endothelial cells. Taken together, these results support the potential use of this nanoparticulate system for systemic administration of drugs.
%A Mariacristina Gagliardi
%A Alice Bertero
%A Giuseppe Bardi
%A Angelo Bifone
%K Biodegradable nanoparticles; Drug delivery; Biodegradation; Biocompatibility; Metoxy polyethyleneglycol-block-poly(?-caprolactone-co-4-hydroxyvalerolactone)
%R 10.1016/j.msec.2015.10.054
%J Materials Science and Engineering: C