eprintid: 3243
rev_number: 9
eprint_status: archive
userid: 69
dir: disk0/00/00/32/43
datestamp: 2016-03-21 09:02:41
lastmod: 2016-03-21 09:19:23
status_changed: 2016-03-21 09:02:41
type: article
metadata_visibility: show
creators_name: Gagliardi, Mariacristina
creators_name: Bertero, Alice
creators_name: Bardi, Giuseppe
creators_name: Bifone, Angelo
creators_id: mariacristina.gagliardi@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
title: A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics
ispublished: pub
subjects: QD
subjects: TA
subjects: TP
divisions: CSA
full_text_status: none
keywords: Biodegradable nanoparticles; Drug delivery; Biodegradation; Biocompatibility; Metoxy polyethyleneglycol-block-poly(ε-caprolactone-co-4-hydroxyvalerolactone)
abstract: Abstract This paper reports the synthesis and the physicochemical, functional and biological characterisations of nanocarriers made of a novel di-block biodegradable poly(ether-ester) copolymer. This material presents tunable, fast biodegradation rates, but its products are less acidic than those of other biosorbable polymers like PLGA, thus presenting a better biocompatibility profile and the possibility to carry pH-sensitive payloads. A method for the production of monodisperse and spherical nanoparticles is proposed; drug delivery kinetics and blood protein adsorption were measured to evaluate the functional properties of these nanoparticles as drug carriers. The copolymer was labelled with a fluorescent dye for internalisation tests, and rhodamine B was used as a model cargo to study transport and release inside cultured cells. Biological tests demonstrated good cytocompatibility, significant cell internalisation and the possibility to vehiculate non-cell penetrating moieties into endothelial cells. Taken together, these results support the potential use of this nanoparticulate system for systemic administration of drugs.
date: 2016
date_type: published
publication: Materials Science and Engineering: C
volume: 59
publisher: Elsevier
pagerange: 488 - 499
id_number: 10.1016/j.msec.2015.10.054
refereed: TRUE
issn: 0928-4931
official_url: http://www.sciencedirect.com/science/article/pii/S0928493115304847
citation:   Gagliardi, Mariacristina and Bertero, Alice and Bardi, Giuseppe and Bifone, Angelo  A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics.  Materials Science and Engineering: C, 59.  488 - 499.  ISSN 0928-4931      (2016)