eprintid: 3244
rev_number: 8
eprint_status: archive
userid: 69
dir: disk0/00/00/32/44
datestamp: 2016-03-21 09:12:52
lastmod: 2016-03-22 11:08:58
status_changed: 2016-03-21 09:12:52
type: article
metadata_visibility: show
creators_name: Gagliardi, Mariacristina
creators_id: mariacristina.gagliardi@imtlucca.it
title: Experimental and computational study of mechanical and transport properties of a polymer coating for drug-eluting stents
ispublished: pub
subjects: QA75
subjects: QD
divisions: CSA
full_text_status: none
abstract: Background: Experimental and computational characterizations in the preclinical development of biomedical devices are complementary and can significantly help in a thorough analysis of the performances before clinical evaluation. Methodology: Here mechanical and drug delivery properties of a polymer platform, ad hoc prepared to obtain coatings for drug-eluting stents, is reported; polymer formulation and starting drug loading were varied to study the behavior of the platform; a finite element model was constructed starting from experimental data. Results: Different platform formulations affected mechanical and drug transport properties; these properties can be fine tuned by varying the starting platform formulation. Finite element analysis allowed visualizing drug distribution maps over time in biological tissues for different commercial stents and polymer platform formulations.
date: 2015
date_type: published
publication: Therapeutic Delivery
volume: 6
number: 11
publisher: Future Science
pagerange: 1255-1268
id_number: 10.4155/tde.15.74
refereed: TRUE
issn: 2041-5990
official_url: http://www.future-science.com/doi/abs/10.4155/tde.15.74?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&
citation:   Gagliardi, Mariacristina  Experimental and computational study of mechanical and transport properties of a polymer coating for drug-eluting stents.  Therapeutic Delivery, 6 (11).  pp. 1255-1268.  ISSN 2041-5990      (2015)