eprintid: 3247
rev_number: 5
eprint_status: archive
userid: 69
dir: disk0/00/00/32/47
datestamp: 2016-03-21 09:24:26
lastmod: 2016-03-21 09:24:26
status_changed: 2016-03-21 09:24:26
type: article
metadata_visibility: show
creators_name: Gagliardi, Mariacristina
creators_id: mariacristina.gagliardi@imtlucca.it
title: Polymeric PEGylated nanoparticles as drug carriers: How preparation and loading procedures influence functional properties
ispublished: pub
subjects: QD
divisions: CSA
full_text_status: none
keywords: Drug delivery systems; Nanoparticles; Nanostructured polymers; Nanowires and nanocrystals
note: Article first published online: 13 AUG 2014
abstract: The application of emerging nanotechnologies in medicine showed in the last years a significant potential in the improvement of therapies. In particular, polymeric nanocarriers are currently tested to evaluate their capability to reduce side effects, to increase the residence time in the body and also to obtain a controlled release over time. In the present work a novel polymeric nanocarrier was developed and optimized to obtain, with the same chemical formulation, three different typologies of nanocarriers: dense nanospheres loaded with an active molecule (1) during nanoparticle formation and (2) after the preparation and (3) hollow nanocapsules to increase the starting drug payload. Synthetic materials considered were PEGylated acrylic copolymers, folic acid was used as model of a hydrophobic drug. The main aim is to develop an optimized nanocarrier for the transport and the enhanced release of poorly water-soluble drugs. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41310.
date: 2015
date_type: published
publication: Journal of Applied Polymer Science
volume: 132
number: 3
publisher: Wiley
id_number: 10.1002/app.41310
refereed: TRUE
issn: 0021-8995
official_url: http://dx.doi.org/10.1002/app.41310
citation:   Gagliardi, Mariacristina  Polymeric PEGylated nanoparticles as drug carriers: How preparation and loading procedures influence functional properties.  Journal of Applied Polymer Science, 132 (3).   ISSN 0021-8995      (2015)