eprintid: 3249
rev_number: 10
eprint_status: archive
userid: 69
dir: disk0/00/00/32/49
datestamp: 2016-03-21 09:32:14
lastmod: 2016-03-21 09:32:14
status_changed: 2016-03-21 09:32:14
type: article
metadata_visibility: show
creators_name: Gamucci, Olimpia
creators_name: Bertero, Alice
creators_name: Gagliardi, Mariacristina
creators_name: Bardi, Giuseppe
creators_id: 
creators_id: 
creators_id: mariacristina.gagliardi@imtlucca.it
creators_id: 
title: Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility
ispublished: pub
subjects: QD
subjects: RS
divisions: CSA
full_text_status: public
keywords: Immune system;	Nanomaterials;	Immunogenicity;	Immunotoxicity;	Biodistribution; Mononuclear phagocytic cells; Surface modifications
abstract: Diagnostic- and therapeutic release-aimed nanoparticles require the highest degree of biocompatibility. Some physical and chemical characteristics of such nanomaterials are often at odds with this requirement. For instance, metals with specific features used as contrast agents in magnetic resonance imaging need particular coatings to improve their blood solubility and increase their biocompatibility. Other examples come from the development of nanocarriers exploiting the different characteristics of two or more materials, i.e., the ability to encapsulate a certain drug by one core-material and the targeting capability of a different coating surface. Furthermore, all these “human-non-self” modifications necessitate proofs of compatibility with the immune system to avoid inflammatory reactions and resultant adverse effects for the patient. In the present review we discuss the molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine.
date: 2014
date_type: published
publication: Coatings
volume: 4
number: 1
publisher: MDPI
pagerange: 139
id_number: 10.3390/coatings4010139
refereed: TRUE
issn: 2079-6412
official_url: http://www.mdpi.com/2079-6412/4/1/139
citation:   Gamucci, Olimpia and Bertero, Alice and Gagliardi, Mariacristina and Bardi, Giuseppe  Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility.  Coatings, 4 (1).  p. 139.  ISSN 2079-6412      (2014)  
document_url: http://eprints.imtlucca.it/3249/2/coatings-04-00139.pdf