<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Surface functionalisation regulates polyamidoamine dendrimer toxicity on blood–brain barrier cells and the modulation of key inflammatory receptors on microglia"^^ . "AbstractDendrimers are branched polymers with spherical morphology. Their tuneable chemistry and surface modification make them valuable nanomaterials for biomedical applications. In view of possible dendrimer uses as brain-aimed nanocarriers, the authors studied amine- and lipid-functionalised (G4) polyamidoamine (PAMAM) biocompatibility with cell population forming the blood–brain barrier (BBB). Both amine-PAMAM and lipid-PAMAM dendrimers were able to enter endothelial and primary neural cells. However, only amine-PAMAM damaged cell membranes in a dose-dependent manner. Transmission electron microscopy evidenced the ability of dendrimers to precipitate salts and serum components present in culture medium that slightly increased toxicity of the amine-PAMAM. Amine- and lipid-PAMAM were both able to cross the BBB and differently induced CD11b and CCR2 overexpression on primary CX3CR1-GFP murine microglia in vitro. These data emphasise the role of dendrimer surface functionalisation in toxicity and neural immune cell activation, raising concerns about possible neuroinflammatory reactions."^^ . "2014" . "8" . "2" . . "Taylor & Francis"^^ . . . "Nanotoxicology"^^ . . . "17435390" . . . . . . . . . . . . . . . . . . . . . . "Alice"^^ . "Bertero"^^ . "Alice Bertero"^^ . . "Mauro"^^ . "Gemmi"^^ . "Mauro Gemmi"^^ . . "Mariacristina"^^ . "Gagliardi"^^ . "Mariacristina Gagliardi"^^ . . "Angelo"^^ . "Bifone"^^ . "Angelo Bifone"^^ . . "Giuseppe"^^ . "Bardi"^^ . "Giuseppe Bardi"^^ . . "Adriano"^^ . "Boni"^^ . "Adriano Boni"^^ . . . . . "HTML Summary of #3251 \n\nSurface functionalisation regulates polyamidoamine dendrimer toxicity on blood–brain barrier cells and the modulation of key inflammatory receptors on microglia\n\n" . "text/html" . . . "QD Chemistry"@en . .