eprintid: 3252
rev_number: 5
eprint_status: archive
userid: 69
dir: disk0/00/00/32/52
datestamp: 2016-03-21 09:44:02
lastmod: 2016-03-21 09:44:02
status_changed: 2016-03-21 09:44:02
type: article
metadata_visibility: show
creators_name: Gagliardi, Mariacristina
creators_name: Bardi, Giuseppe
creators_name: Bifone, Angelo
creators_id: mariacristina.gagliardi@imtlucca.it
creators_id: 
creators_id: 
title: Polymeric nanocarriers for controlled and enhanced delivery of therapeutic agents to the CNS
ispublished: pub
subjects: QD
divisions: CSA
full_text_status: none
abstract: Polymeric nanocarriers are versatile structures that can be engineered to obtain high drug loading, good delivery yields and tunable release kinetics. Moreover, the particle surface can be modified for selective targeting of organs or tissues. In particular, polymeric nanocarriers can be conjugated with functional groups promoting translocation through the blood–brain barrier, thus providing a promising system to deliver therapeutic agents and/or diagnostic probes to the brain. Here we review recent literature on the preparation and characterization of polymeric nanoparticles as potential agents for drug delivery to the CNS, with an emphasis on materials chemistry and functionalization strategies for improved selectivity and delivery. Finally, we underline the immunotoxicological aspects of this class of nanostructured materials in view of potential clinical applications.
date: 2012
date_type: published
publication: Therapeutic Delivery
volume: 3
number: 7
publisher: Future Science
pagerange: 875-887
id_number: 10.4155/tde.12.55
refereed: TRUE
issn: 2041-5990
official_url: http://www.future-science.com/doi/abs/10.4155/tde.12.55
citation:   Gagliardi, Mariacristina and Bardi, Giuseppe and Bifone, Angelo  Polymeric nanocarriers for controlled and enhanced delivery of therapeutic agents to the CNS.  Therapeutic Delivery, 3 (7).  pp. 875-887.  ISSN 2041-5990      (2012)