eprintid: 3253
rev_number: 5
eprint_status: archive
userid: 69
dir: disk0/00/00/32/53
datestamp: 2016-03-21 09:45:38
lastmod: 2016-03-21 09:45:38
status_changed: 2016-03-21 09:45:38
type: article
metadata_visibility: show
creators_name: Gagliardi, Mariacristina
creators_id: mariacristina.gagliardi@imtlucca.it
title: In vitro haematic proteins adsorption and cytocompatibility study on acrylic copolymer to realise coatings for drug-eluting stents
ispublished: pub
subjects: QD
divisions: CSA
full_text_status: none
keywords: Protein adsorption; Cytocompatibility; Cell culture tests; C2C12; Drug-eluting coatings; Paclitaxel
abstract: In the present paper, a preliminary in vitro analysis of biocompatibility of newly-synthesised acrylic copolymers is reported. In particular, with the aim to obtain coatings for drug-eluting stents, blood protein absorption and cytocompatibility were studied. For protein absorption tests, bovine serum albumin and bovine plasma fibrinogen were considered. Cytocompatibility was tested using {C2C12} cell line as model, analysing the behaviour of polymeric matrices and of drug-eluting systems, obtained loading polymeric matrices with paclitaxel, an anti-mitotic drug, in order to evaluate the efficacy of a pharmacological treatment locally administered from these materials. Results showed that the amount of albumin absorbed was greater than the amount of fibrinogen (comprised in the range of 70–85 and 10–22 respectively) and it is a good behaviour in terms of haemocompatibility. Cell culture tests showed good adhesion properties and a relative poor proliferation. In addition, a strong effect related to drug elution and a correlation with the macromolecular composition were detected. In this preliminary analysis, tested materials showed good characteristics and can be considered possible candidates to obtain coatings for drug-eluting stents.
date: 2012
date_type: published
publication: Materials Science and Engineering: C
volume: 32
number: 8
publisher: Elsevier
pagerange: 2445 - 2451
id_number: 10.1016/j.msec.2012.07.020
refereed: TRUE
issn: 0928-4931
official_url: http://www.sciencedirect.com/science/article/pii/S0928493112003384
citation:   Gagliardi, Mariacristina  In vitro haematic proteins adsorption and cytocompatibility study on acrylic copolymer to realise coatings for drug-eluting stents.  Materials Science and Engineering: C, 32 (8).  2445 - 2451.  ISSN 0928-4931      (2012)