eprintid: 3254
rev_number: 5
eprint_status: archive
userid: 69
dir: disk0/00/00/32/54
datestamp: 2016-03-21 09:48:43
lastmod: 2016-03-21 09:48:43
status_changed: 2016-03-21 09:48:43
type: article
metadata_visibility: show
creators_name: Cristallini, Caterina
creators_name: Gagliardi, Mariacristina
creators_name: Barbani, Niccoletta
creators_name: Giannessi, Daniela
creators_name: Guerra, Giulio D.
creators_id: 
creators_id: mariacristina.gagliardi@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
title: Novel biodegradable, biomimetic and functionalised polymer scaffolds to prevent expansion of post-infarct left ventricular remodelling
ispublished: pub
subjects: QD
divisions: CSA
full_text_status: none
abstract: Over the past decade, a large number of strategies and technologies have been developed to reduce heart failure progression. Among these, cardiac tissue engineering is one of the most promising. Aim of this study is to develop a 3D scaffold to treat cardiac failure. A new three-block copolymer, obtained from δ-valerolactone and polyoxyethylene, was synthesised under high vacuum without catalyst. Copolymer/gelatine blends were microfabricated to obtain a ECM-like geometry. Structures were studied under morphological, mechanical, degradation and biological aspects. To prevent left ventricular remodelling, constructs were biofunctionalises with molecularly imprinted nanoparticles towards the matrix metalloproteinase MMP-9. Results showed that materials are able to reproduce the ECM structure with high resolution, mechanical properties were in the order of MPa similar to those of the native myocardium and cell viability was verified. Nanoparticles showed the capability to rebind MMP-9 (specific rebinding 18.67) and to be permanently immobilised on the scaffold surface.
date: 2011
date_type: published
publication: Journal of Materials Science: Materials in Medicine
volume: 23
number: 1
publisher: Springer
pagerange: 205-216
id_number: 10.1007/s10856-011-4506-1
refereed: TRUE
issn: 0957-4530
official_url: http://dx.doi.org/10.1007/s10856-011-4506-1
citation:   Cristallini, Caterina and Gagliardi, Mariacristina and Barbani, Niccoletta and Giannessi, Daniela and Guerra, Giulio D.  Novel biodegradable, biomimetic and functionalised polymer scaffolds to prevent expansion of post-infarct left ventricular remodelling.  Journal of Materials Science: Materials in Medicine, 23 (1).  pp. 205-216.  ISSN 0957-4530      (2011)