eprintid: 3255
rev_number: 10
eprint_status: archive
userid: 69
dir: disk0/00/00/32/55
datestamp: 2016-03-21 09:53:21
lastmod: 2016-04-06 07:42:52
status_changed: 2016-03-21 09:53:21
type: article
metadata_visibility: show
creators_name: Guerra, Giulio D.
creators_name: Barbani, Niccoletta
creators_name: Gagliardi, Mariacristina
creators_name: Rosellini, Elisabetta
creators_name: Cristallini, Caterina
creators_id: 
creators_id: 
creators_id: mariacristina.gagliardi@imtlucca.it
creators_id: 
creators_id: 
title: Chitosan-Based Macromolecular Biomaterials for the Regeneration of Chondroskeletal and Nerve Tissue
ispublished: pub
subjects: QD
divisions: CSA
full_text_status: public
abstract: The use of materials, containing the biocompatible and bioresorbable biopolymer poly()-2-amino-2-deoxy--D-glucan, containing some N-acetyl-glucosamine units (chitosan, CHI) and/or its derivatives, to fabricate devices for the regeneration of bone, cartilage and nerve tissue, was reviewed. The CHI-containing devices, to be used for bone and cartilage regeneration and healing, were tested mainly for in vitro cell adhesion and proliferation and for insertion into animals; only the use of CHI in dental surgery has reached the clinical application. Regarding the nerve tissue, only a surgical repair of a 35 mm-long nerve defect in the median nerve of the right arm at elbow level with an artificial nerve graft, comprising an outer microporous conduit of CHI and internal oriented filaments of poly(glycolic acid), was reported. As a consequence, although many positive results have been obtained, much work must still be made, especially for the passage from the experimentation of the CHI-based devices, in vitro and in animals, to their clinical application.
date: 2011
date_type: published
publication: International Journal of Carbohydrate Chemistry
volume: 2011
publisher: Hindawi Publishing Corporation
pagerange: 303708
id_number: 10.1155/2011/303708
refereed: TRUE
issn: 1687-9341
official_url: http://www.hindawi.com/journals/ijcc/2011/303708/
citation:   Guerra, Giulio D. and Barbani, Niccoletta and Gagliardi, Mariacristina and Rosellini, Elisabetta and Cristallini, Caterina  Chitosan-Based Macromolecular Biomaterials for the Regeneration of Chondroskeletal and Nerve Tissue.  International Journal of Carbohydrate Chemistry, 2011.  p. 303708.  ISSN 1687-9341      (2011)  
document_url: http://eprints.imtlucca.it/3255/1/303708.pdf