eprintid: 3256
rev_number: 9
eprint_status: archive
userid: 69
dir: disk0/00/00/32/56
datestamp: 2016-03-21 09:59:36
lastmod: 2016-04-06 07:42:12
status_changed: 2016-03-21 09:59:36
type: article
metadata_visibility: show
creators_name: Guerra, Giulio D.
creators_name: Cristallini, Caterina
creators_name: Barbani, Niccoletta
creators_name: Gagliardi, Mariacristina
creators_id: 
creators_id: 
creators_id: 
creators_id: mariacristina.gagliardi@imtlucca.it
title: Bioresorbable microspheres as devices for the controlled release of paclitaxel
ispublished: pub
subjects: QD
divisions: CSA
full_text_status: public
keywords: Controlled release, microspheres, paclitaxel,
poly(ester-ether-ester)s, polyurethanes.
abstract: The release of the anti-cancer drug paclitaxel (PTX) from microspheres of both a bioresorbable poly(ε-caprolactoneoxyethylene- ε-caprolactone) tri-block copolymer and of polyurethanes containing either copolymers with the same composition and different molecular weights or poly(ε-caprolactone) diol as soft segments was studied. The microspheres, both loaded and not with PTX, were prepared by emulsion-evaporation technique, then characterized by SEM and DSC. The quantities of PTX released were measured by HPLC. The results showed slow and very regular releases, which fit very well the Peppas equation, Mt/M? = k · tn, where Mt is the amount of solute released at the time t, M? is the amount of drug released at the plateau condition, k represents the Peppas kinetic constant and n the diffusion order. Most n values are consistent with non-Fickian release mechanisms, with the exceptions of two less hydrophilic polyurethanes.
date: 2011
date_type: published
publication: International Journal of Biology and Biomedical Engineering
volume: 5
number: 3
publisher: North Atlantic University Union
pagerange: 121-128
refereed: TRUE
issn: 1998-4510
official_url: http://www.naun.org/main/NAUN/bio/2011.html
citation:   Guerra, Giulio D. and Cristallini, Caterina and Barbani, Niccoletta and Gagliardi, Mariacristina  Bioresorbable microspheres as devices for the controlled release of paclitaxel.  International Journal of Biology and Biomedical Engineering, 5 (3).  pp. 121-128.  ISSN 1998-4510      (2011)  
document_url: http://eprints.imtlucca.it/3256/1/20-634.pdf