TY  - CHAP
T2  - Recent Researches in Modern Medicine
EP  - 217
ID  - eprints3257
UR  - http://eprints.imtlucca.it/3257/
Y1  - 2011///
TI  - Controlled Release of the Anti-cancer Drug Paclitaxel from Bioresorbable Poly(ester-ether-ester) Microspheres
AV  - none
N2  - The release of the anti-cancer drug paclitaxel (PTX) from microspheres of the bioresorbable poly(?-caprolactoneoxyethylene-?-caprolactone)tri-block copolymer was studied. The microspheres, both loaded and not with PTX, were prepared by emulsion-evaporation technique, then characterized by SEM, AFM, total reflection and spotlight FT-IR spectroscopy, and DSC. The quantities of PTX released were measured by HPLC. The results showed a slow and very regular release, which fits very well the Peppas equation, Mt/M? = k · t, where Mt is the amount of solute released at the time t, M? is the amount of drug released at the plateau condition, k represents the Peppas kinetic constant and n the diffusion order.
SP  - 210
SN  - 9789604742783
PB  - WSEAS
A1  - Guerra, Giulio D.
A1  - Gagliardi, Mariacristina
A1  - Barbani, Niccoletta
A1  - Cristallini, Caterina
ER  -