%L eprints3257
%I WSEAS
%X The release of the anti-cancer drug paclitaxel (PTX) from microspheres of the bioresorbable poly(?-caprolactoneoxyethylene-?-caprolactone)tri-block copolymer was studied. The microspheres, both loaded and not with PTX, were prepared by emulsion-evaporation technique, then characterized by SEM, AFM, total reflection and spotlight FT-IR spectroscopy, and DSC. The quantities of PTX released were measured by HPLC. The results showed a slow and very regular release, which fits very well the Peppas equation, Mt/M? = k ? t, where Mt is the amount of solute released at the time t, M? is the amount of drug released at the plateau condition, k represents the Peppas kinetic constant and n the diffusion order.
%D 2011
%A Giulio D. Guerra
%A Mariacristina Gagliardi
%A Niccoletta Barbani
%A Caterina Cristallini
%B Recent Researches in Modern Medicine
%T Controlled Release of the Anti-cancer Drug Paclitaxel from Bioresorbable Poly(ester-ether-ester) Microspheres
%P 210-217