eprintid: 3257
rev_number: 10
eprint_status: archive
userid: 69
dir: disk0/00/00/32/57
datestamp: 2016-03-21 10:45:55
lastmod: 2016-04-06 07:44:40
status_changed: 2016-03-21 10:45:55
type: book_section
metadata_visibility: show
creators_name: Guerra, Giulio D.
creators_name: Gagliardi, Mariacristina
creators_name: Barbani, Niccoletta
creators_name: Cristallini, Caterina
creators_id: 
creators_id: mariacristina.gagliardi@imtlucca.it
creators_id: 
creators_id: 
title: Controlled Release of the Anti-cancer Drug Paclitaxel from Bioresorbable Poly(ester-ether-ester) Microspheres
ispublished: pub
subjects: QD
subjects: RZ
divisions: CSA
full_text_status: none
abstract: The release of the anti-cancer drug paclitaxel (PTX) from microspheres of the bioresorbable poly(ε-caprolactoneoxyethylene-ε-caprolactone)tri-block copolymer was studied. The microspheres, both loaded and not with PTX, were prepared by emulsion-evaporation technique, then characterized by SEM, AFM, total reflection and spotlight FT-IR spectroscopy, and DSC. The quantities of PTX released were measured by HPLC. The results showed a slow and very regular release, which fits very well the Peppas equation, Mt/M∞ = k · t, where Mt is the amount of solute released at the time t, M∞ is the amount of drug released at the plateau condition, k represents the Peppas kinetic constant and n the diffusion order.
date: 2011
date_type: published
publisher: WSEAS
pagerange: 210-217
pages: 8
refereed: TRUE
isbn: 9789604742783
book_title: Recent Researches in Modern Medicine
related_url_url: http://www.wseas.org/wseas/cms.action?id=2741
related_url_type: org
citation:   Guerra, Giulio D. and Gagliardi, Mariacristina and Barbani, Niccoletta and Cristallini, Caterina  Controlled Release of the Anti-cancer Drug Paclitaxel from Bioresorbable Poly(ester-ether-ester) Microspheres.   In:  Recent Researches in Modern Medicine.   WSEAS, pp. 210-217.  ISBN 9789604742783      (2011)