TY  - JOUR
VL  - 93B
Y1  - 2010///
IS  - 2
JF  - Journal of Biomedical Materials Research Part B: Applied Biomaterials
A1  - Gagliardi, Mariacristina
A1  - Silvestri, Davide
A1  - Cristallini, Caterina
A1  - Guadagni, M.
A1  - Crifaci, G.
A1  - Giusti, Paolo
PB  - Wiley
SP  - 375
ID  - eprints3261
EP  - 385
AV  - none
TI  - Combined drug release from biodegradable bilayer coating for endovascular stents
KW  - Biodegradation; Coating(s); Controlled release; Vascular stents; Combined drug delivery
UR  - http://dx.doi.org/10.1002/jbm.b.31592
SN  - 1552-4973
N2  - In this work, the characterization of a biodegradable bilayer system, used as controlled and combined drug delivery platform, is reported. For this aim, a bilayer system, composed of poly(lactic-co-glycolic acid) and poly(3-hydroxybutyric-co-3-hydroxyvaleric acid), was investigated under physicochemical and functional aspects by evaluating polymer/polymer and polymer/stent material interactions, the kinetic of in vitro degradation, and drug release properties, comparing results with the monolayer reference systems. Obtained results showed that the bilayer system allowed increasing the total amount of eluted Tacrolimus and Paclitaxel drugs with respect to the monolayer systems in the considered testing period and conditions. This evidence was associated to a faster degradation of the tested copolymers in the bilayered configuration, excluding a synergic effect of two drugs on delivery performance. In addition, a macromolecular relaxation process was identified to govern the PLX release from poly(lactic-co-glycolic acid), whereas a pure Fickian diffusion occurred in the delivery of Tacrolimus from poly(3-hydroxybutyric-co-3-hydroxyvaleric acid). © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010
ER  -