eprintid: 3261
rev_number: 6
eprint_status: archive
userid: 69
dir: disk0/00/00/32/61
datestamp: 2016-03-21 11:22:41
lastmod: 2016-04-05 12:18:04
status_changed: 2016-03-21 11:22:41
type: article
metadata_visibility: show
creators_name: Gagliardi, Mariacristina
creators_name: Silvestri, Davide
creators_name: Cristallini, Caterina
creators_name: Guadagni, M.
creators_name: Crifaci, G.
creators_name: Giusti, Paolo
creators_id: mariacristina.gagliardi@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: Combined drug release from biodegradable bilayer coating for endovascular stents
ispublished: pub
subjects: QD
divisions: CSA
full_text_status: none
keywords: Biodegradation; Coating(s); Controlled release; Vascular stents; Combined drug delivery
abstract: In this work, the characterization of a biodegradable bilayer system, used as controlled and combined drug delivery platform, is reported. For this aim, a bilayer system, composed of poly(lactic-co-glycolic acid) and poly(3-hydroxybutyric-co-3-hydroxyvaleric acid), was investigated under physicochemical and functional aspects by evaluating polymer/polymer and polymer/stent material interactions, the kinetic of in vitro degradation, and drug release properties, comparing results with the monolayer reference systems. Obtained results showed that the bilayer system allowed increasing the total amount of eluted Tacrolimus and Paclitaxel drugs with respect to the monolayer systems in the considered testing period and conditions. This evidence was associated to a faster degradation of the tested copolymers in the bilayered configuration, excluding a synergic effect of two drugs on delivery performance. In addition, a macromolecular relaxation process was identified to govern the PLX release from poly(lactic-co-glycolic acid), whereas a pure Fickian diffusion occurred in the delivery of Tacrolimus from poly(3-hydroxybutyric-co-3-hydroxyvaleric acid). © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010
date: 2010
date_type: published
publication: Journal of Biomedical Materials Research Part B: Applied Biomaterials
volume: 93B
number: 2
publisher: Wiley
pagerange: 375-385
id_number: 10.1002/jbm.b.31592
refereed: TRUE
issn: 1552-4973
official_url: http://dx.doi.org/10.1002/jbm.b.31592
citation:   Gagliardi, Mariacristina and Silvestri, Davide and Cristallini, Caterina and Guadagni, M. and Crifaci, G. and Giusti, Paolo  Combined drug release from biodegradable bilayer coating for endovascular stents.  Journal of Biomedical Materials Research Part B: Applied Biomaterials, 93B (2).  pp. 375-385.  ISSN 1552-4973      (2010)