relation: http://eprints.imtlucca.it/3263/
title: Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel
creator: Silvestri, Davide
creator: Gagliardi, Mariacristina
creator: Barbani, Niccoletta
creator: Cristallini, Caterina
creator: Giusti, Paolo
subject: QD Chemistry
description: The aim of the present work is the modification of a hydrophobic polymeric macromolecule, polymethylmethacrylate, by introducing hydrophilic moieties of 2-hydroxyethyl methacrylate within the polymer chain. Synthesis, characterization, and drug delivery control capabilities exerted on a highly hydrophobic drug (Paclitaxel) are illustrated. In particular, the dependency of the drug delivery kinetic on the fraction of hydrophilic units inserted in the copolymer chain was studied. Results showed that it is possible to have an increase of the kinetic delivery introducing hydrophilic units. In addition, a double control, diffusive and due to the relaxation of the molecules, on drug delivery was obtained.
publisher: Taylor and Francis
date: 2009
type: Article
type: PeerReviewed
identifier:   Silvestri, Davide and Gagliardi, Mariacristina and Barbani, Niccoletta and Cristallini, Caterina and Giusti, Paolo  Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel.  Drug Delivery, 16 (2).  pp. 116-124.  ISSN 1071-7544      (2009)  
relation: http://dx.doi.org/10.1080/10717540802666980
relation: 10.1080/10717540802666980