TY  - JOUR
ID  - eprints3263
SP  - 116
Y1  - 2009///
JF  - Drug Delivery
AV  - none
IS  - 2
UR  - http://dx.doi.org/10.1080/10717540802666980
N1  - Acrylic copolymer; Poly[(methyl methacrylate)-co-(2-hydroxyethyl methacrylate)]; Drug delivery polymers; Controlled drug release
PB  - Taylor and Francis
VL  - 16
SN  - 1071-7544
A1  - Silvestri, Davide
A1  - Gagliardi, Mariacristina
A1  - Barbani, Niccoletta
A1  - Cristallini, Caterina
A1  - Giusti, Paolo
N2  - The aim of the present work is the modification of a hydrophobic polymeric macromolecule, polymethylmethacrylate, by introducing hydrophilic moieties of 2-hydroxyethyl methacrylate within the polymer chain. Synthesis, characterization, and drug delivery control capabilities exerted on a highly hydrophobic drug (Paclitaxel) are illustrated. In particular, the dependency of the drug delivery kinetic on the fraction of hydrophilic units inserted in the copolymer chain was studied. Results showed that it is possible to have an increase of the kinetic delivery introducing hydrophilic units. In addition, a double control, diffusive and due to the relaxation of the molecules, on drug delivery was obtained.
EP  - 124
TI  - Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel
ER  -