eprintid: 3263
rev_number: 6
eprint_status: archive
userid: 69
dir: disk0/00/00/32/63
datestamp: 2016-03-21 12:23:37
lastmod: 2016-03-21 12:23:37
status_changed: 2016-03-21 12:23:37
type: article
metadata_visibility: show
creators_name: Silvestri, Davide
creators_name: Gagliardi, Mariacristina
creators_name: Barbani, Niccoletta
creators_name: Cristallini, Caterina
creators_name: Giusti, Paolo
creators_id: 
creators_id: mariacristina.gagliardi@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
title: Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel
ispublished: pub
subjects: QD
divisions: CSA
full_text_status: none
note: Acrylic copolymer; Poly[(methyl methacrylate)-co-(2-hydroxyethyl methacrylate)]; Drug delivery polymers; Controlled drug release
abstract: The aim of the present work is the modification of a hydrophobic polymeric macromolecule, polymethylmethacrylate, by introducing hydrophilic moieties of 2-hydroxyethyl methacrylate within the polymer chain. Synthesis, characterization, and drug delivery control capabilities exerted on a highly hydrophobic drug (Paclitaxel) are illustrated. In particular, the dependency of the drug delivery kinetic on the fraction of hydrophilic units inserted in the copolymer chain was studied. Results showed that it is possible to have an increase of the kinetic delivery introducing hydrophilic units. In addition, a double control, diffusive and due to the relaxation of the molecules, on drug delivery was obtained.
date: 2009
date_type: published
publication: Drug Delivery
volume: 16
number: 2
publisher: Taylor and Francis
pagerange: 116-124
id_number: 10.1080/10717540802666980
refereed: TRUE
issn: 1071-7544
official_url: http://dx.doi.org/10.1080/10717540802666980
citation:   Silvestri, Davide and Gagliardi, Mariacristina and Barbani, Niccoletta and Cristallini, Caterina and Giusti, Paolo  Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel.  Drug Delivery, 16 (2).  pp. 116-124.  ISSN 1071-7544      (2009)