relation: http://eprints.imtlucca.it/3264/
title: Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents
creator: Silvestri, Davide
creator: Cristallini, Caterina
creator: Gagliardi, Mariacristina
creator: Barbani, Niccoletta
creator: D'Acunto, M.
creator: Ciardelli, G.
creator: Giusti, Paolo
subject: QD Chemistry
description: The aim of the present work is the synthesis and characterization of polymer materials showing good adhesion, drug loading, and delivery properties, for potential cardiovascular application. In particular, poly(methylmethacrylate-co-acrylic acid) copolymers are prepared in different compositions by a radical polymerization and investigated as potential materials to coat metallic stents and to carry out a local drug release. Films obtained by dissolving the copolymer in an appropriate organic solvent (also loaded with an anti-restenosis drug, such as tacrolimus) are investigated: physicochemical properties, adhesiveness to metallic stent material, and kinetics of drug release in physiological environment are studied.
publisher: Sage
date: 2009
type: Article
type: PeerReviewed
identifier:   Silvestri, Davide and Cristallini, Caterina and Gagliardi, Mariacristina and Barbani, Niccoletta and D'Acunto, M. and Ciardelli, G. and Giusti, Paolo  Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents.  Journal of Biomaterials Applications, 24 (4).  pp. 353-383.  ISSN 0885-3282      (2009)  
relation: http://jba.sagepub.com/content/24/4/353.abstract
relation: 10.1177/0885328208095198