TY  - JOUR
TI  - Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents
AV  - none
Y1  - 2009///
UR  - http://jba.sagepub.com/content/24/4/353.abstract
JF  - Journal of Biomaterials Applications
IS  - 4
A1  - Silvestri, Davide
A1  - Cristallini, Caterina
A1  - Gagliardi, Mariacristina
A1  - Barbani, Niccoletta
A1  - D'Acunto, M.
A1  - Ciardelli, G.
A1  - Giusti, Paolo
PB  - Sage
SN  - 0885-3282
N2  - The aim of the present work is the synthesis and characterization of polymer materials showing good adhesion, drug loading, and delivery properties, for potential cardiovascular application. In particular, poly(methylmethacrylate-co-acrylic acid) copolymers are prepared in different compositions by a radical polymerization and investigated as potential materials to coat metallic stents and to carry out a local drug release. Films obtained by dissolving the copolymer in an appropriate organic solvent (also loaded with an anti-restenosis drug, such as tacrolimus) are investigated: physicochemical properties, adhesiveness to metallic stent material, and kinetics of drug release in physiological environment are studied.
SP  - 353
ID  - eprints3264
EP  - 383
VL  - 24
ER  -