%V 24
%L eprints3264
%N 4
%A Davide Silvestri
%A Caterina Cristallini
%A Mariacristina Gagliardi
%A Niccoletta Barbani
%A M. D'Acunto
%A G. Ciardelli
%A Paolo Giusti
%J Journal of Biomaterials Applications
%D 2009
%R 10.1177/0885328208095198
%X The aim of the present work is the synthesis and characterization of polymer materials showing good adhesion, drug loading, and delivery properties, for potential cardiovascular application. In particular, poly(methylmethacrylate-co-acrylic acid) copolymers are prepared in different compositions by a radical polymerization and investigated as potential materials to coat metallic stents and to carry out a local drug release. Films obtained by dissolving the copolymer in an appropriate organic solvent (also loaded with an anti-restenosis drug, such as tacrolimus) are investigated: physicochemical properties, adhesiveness to metallic stent material, and kinetics of drug release in physiological environment are studied.
%I Sage
%P 353-383
%T Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents