eprintid: 3264
rev_number: 5
eprint_status: archive
userid: 69
dir: disk0/00/00/32/64
datestamp: 2016-03-21 12:25:50
lastmod: 2016-03-21 12:25:50
status_changed: 2016-03-21 12:25:50
type: article
metadata_visibility: show
creators_name: Silvestri, Davide
creators_name: Cristallini, Caterina
creators_name: Gagliardi, Mariacristina
creators_name: Barbani, Niccoletta
creators_name: D'Acunto, M.
creators_name: Ciardelli, G.
creators_name: Giusti, Paolo
creators_id: 
creators_id: 
creators_id: mariacristina.gagliardi@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents
ispublished: pub
subjects: QD
divisions: CSA
full_text_status: none
abstract: The aim of the present work is the synthesis and characterization of polymer materials showing good adhesion, drug loading, and delivery properties, for potential cardiovascular application. In particular, poly(methylmethacrylate-co-acrylic acid) copolymers are prepared in different compositions by a radical polymerization and investigated as potential materials to coat metallic stents and to carry out a local drug release. Films obtained by dissolving the copolymer in an appropriate organic solvent (also loaded with an anti-restenosis drug, such as tacrolimus) are investigated: physicochemical properties, adhesiveness to metallic stent material, and kinetics of drug release in physiological environment are studied.
date: 2009
date_type: published
publication: Journal of Biomaterials Applications
volume: 24
number: 4
publisher: Sage
pagerange: 353-383
id_number: 10.1177/0885328208095198
refereed: TRUE
issn: 0885-3282
official_url: http://jba.sagepub.com/content/24/4/353.abstract
citation:   Silvestri, Davide and Cristallini, Caterina and Gagliardi, Mariacristina and Barbani, Niccoletta and D'Acunto, M. and Ciardelli, G. and Giusti, Paolo  Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents.  Journal of Biomaterials Applications, 24 (4).  pp. 353-383.  ISSN 0885-3282      (2009)