relation: http://eprints.imtlucca.it/3323/
title: A 3h-flunitrazepam binding inhibitor is present in psychiatric patients’sera
creator: Marazziti, Donatella
creator: Pietrini, Pietro
creator: Martini, Claudia
creator: Giannaccini, Gino
creator: Perugi, Giulio
creator: Placidi, Gian Franco
creator: Cassano, Giovanni Battista
creator: Lucacchini, Antonio
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: We investigated the possible existence of endogenous compounds acting on benzodiazepine central receptors in the serum of patients with panic attacks or depression. Our results show the presence of a substance which inhibits the 3H-fiunitrazepam binding specifically in the samples taken from the patients’ groups, and which is not present in normal controls, in the range of concentrations used. This compound has a molecular weight below 1,000 daltons, is heat-stable, and resistant to proteolytic degradation. The demonstration of this inhibitor opens new perspectives in the study of the biochemistry of anxiety.
publisher: Karger
date: 1987
type: Article
type: PeerReviewed
identifier:   Marazziti, Donatella and Pietrini, Pietro and Martini, Claudia and Giannaccini, Gino and Perugi, Giulio and Placidi, Gian Franco and Cassano, Giovanni Battista and Lucacchini, Antonio  A 3h-flunitrazepam binding inhibitor is present in psychiatric patients’sera.  Neuropsychobiology, 18 (2).  pp. 74-76.  ISSN 0302-282X      (1987)  
relation: http://www.karger.com/Article/Abstract/118396#
relation: 10.1159/000118396