TY  - JOUR
VL  - 18
ID  - eprints3323
EP  - 76
PB  - Karger
SN  - 0302-282X
A1  - Marazziti, Donatella
A1  - Pietrini, Pietro
A1  - Martini, Claudia
A1  - Giannaccini, Gino
A1  - Perugi, Giulio
A1  - Placidi, Gian Franco
A1  - Cassano, Giovanni Battista
A1  - Lucacchini, Antonio
N2  - We investigated the possible existence of endogenous compounds acting on benzodiazepine central receptors in the serum of patients with panic attacks or depression. Our results show the presence of a substance which inhibits the 3H-fiunitrazepam binding specifically in the samples taken from the patients? groups, and which is not present in normal controls, in the range of concentrations used. This compound has a molecular weight below 1,000 daltons, is heat-stable, and resistant to proteolytic degradation. The demonstration of this inhibitor opens new perspectives in the study of the biochemistry of anxiety.
SP  - 74
Y1  - 1987///
TI  - A 3h-flunitrazepam binding inhibitor is present in psychiatric patients?sera
AV  - none
JF  - Neuropsychobiology
IS  - 2
UR  - http://www.karger.com/Article/Abstract/118396#
ER  -