eprintid: 3323
rev_number: 6
eprint_status: archive
userid: 69
dir: disk0/00/00/33/23
datestamp: 2016-03-23 13:33:53
lastmod: 2016-04-06 07:11:35
status_changed: 2016-03-23 13:33:53
type: article
metadata_visibility: show
creators_name: Marazziti, Donatella
creators_name: Pietrini, Pietro
creators_name: Martini, Claudia
creators_name: Giannaccini, Gino
creators_name: Perugi, Giulio
creators_name: Placidi, Gian Franco
creators_name: Cassano, Giovanni Battista
creators_name: Lucacchini, Antonio
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: A 3h-flunitrazepam binding inhibitor is present in psychiatric patients’sera
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
abstract: We investigated the possible existence of endogenous compounds acting on benzodiazepine central receptors in the serum of patients with panic attacks or depression. Our results show the presence of a substance which inhibits the 3H-fiunitrazepam binding specifically in the samples taken from the patients’ groups, and which is not present in normal controls, in the range of concentrations used. This compound has a molecular weight below 1,000 daltons, is heat-stable, and resistant to proteolytic degradation. The demonstration of this inhibitor opens new perspectives in the study of the biochemistry of anxiety.
date: 1987
date_type: published
publication: Neuropsychobiology
volume: 18
number: 2
publisher: Karger
pagerange: 74-76
id_number: 10.1159/000118396
refereed: TRUE
issn: 0302-282X
official_url: http://www.karger.com/Article/Abstract/118396#
citation:   Marazziti, Donatella and Pietrini, Pietro and Martini, Claudia and Giannaccini, Gino and Perugi, Giulio and Placidi, Gian Franco and Cassano, Giovanni Battista and Lucacchini, Antonio  A 3h-flunitrazepam binding inhibitor is present in psychiatric patients’sera.  Neuropsychobiology, 18 (2).  pp. 74-76.  ISSN 0302-282X      (1987)