eprintid: 3325
rev_number: 6
eprint_status: archive
userid: 69
dir: disk0/00/00/33/25
datestamp: 2016-03-23 13:38:24
lastmod: 2016-04-05 12:38:22
status_changed: 2016-03-23 13:38:24
type: article
metadata_visibility: show
creators_name: Horwitz, Barry
creators_name: Swedo, Susan E.
creators_name: Grady, Cheryl L.
creators_name: Pietrini, Pietro
creators_name: Schapiro, Mark B.
creators_name: Rapoport, Judith L.
creators_name: Rapoport, Stanley I.
creators_id: 
creators_id: 
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
title: Cerebral metabolic pattern in obsessive-compulsive disorder: Altered intercorrelations between regional rates of glucose utilization
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
note: Obsessive-compulsive disorder; positron emission tomography; correlation analysis; glucose metabolism; brain
abstract: Correlations between normalized regional cerebral metabolic rates for glucose, determined by positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose, were used to investigate functional associations between pairs of brain regions in 18 adult patients with primary obsessive-compulsive disorder (OCD) of childhood-onset, as compared with 18 age- and sex-matched control subjects. The number of correlations that differed significantly between the two groups exceeded chance, although as many of these correlations were larger in the OCD group relative to controls as were smaller. The two regions that had the largest number of correlations that differed significantly between groups were a left hemisphere superior parietal region and the left hemisphere anterior medial temporal area (which includes principally the amygdala). Correlations involving the caudate nuclei did not differ between the two groups for the most part. Anterior limbic/paralimbic regions had correlations in the OCD group that were significantly larger with frontal areas than in controls, and correlations that were significantly smaller with posterior brain regions. This pattern was especially pronounced for the left hemisphere anterior medial temporal region. These results suggest that the correlation pattern in OCD is not characterized by an overall loss of functional integration but, rather, by functional reorganization.
date: 1991
date_type: published
publication: Psychiatry Research: Neuroimaging
volume: 40
number: 4
publisher: Elsevier
pagerange: 221-237
id_number: 10.1016/0925-4927(91)90014-H
refereed: TRUE
issn: 0925-4927
official_url: http://biblioproxy.cnr.it:2052/science/article/pii/092549279190014H
citation:   Horwitz, Barry and Swedo, Susan E. and Grady, Cheryl L. and Pietrini, Pietro and Schapiro, Mark B. and Rapoport, Judith L. and Rapoport, Stanley I.  Cerebral metabolic pattern in obsessive-compulsive disorder: Altered intercorrelations between regional rates of glucose utilization.  Psychiatry Research: Neuroimaging, 40 (4).  pp. 221-237.  ISSN 0925-4927      (1991)