relation: http://eprints.imtlucca.it/3326/
title: Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder: Revisualization during Pharmacotherapy
creator: Swedo, Susan E.
creator: Pietrini, Pietro
creator: Leonard, Henrietta L.
creator: Schapiro, Mark B.
creator: Rettew, David C.
creator: Goldberger, Erica L.
creator: Rapoport, Stanley I.
creator: Rapoport, Judith L.
creator: Grady, Cheryl L.
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: To investigate the effects of drug treatment in childhoodonset obsessive-compulsive disorder (OCD), we repeated positron emission tomographic scans in 13 adults with OCD (eight taking clomipramine, two taking fluoxetine, and three taking no drug) after at least 1 year of pharmacotherapy. As a group, the patients had a significant improvement on all OCD and anxiety ratings. Positron emission tomography revealed a significant decrease in normalized orbitofrontal regional cerebral glucose metabolism (relative to global metabolism) bilaterally. Among the treated patients, the decrease in right orbitofrontal metabolism was directly correlated with two measures of OCD improvement. These results extend previous positron emission tomographic findings of regional dysfunction in OCD and suggest involvement of the orbitofrontal regions in the pathophysiology of OCD.
publisher: American Medical Association
date: 1992
type: Article
type: PeerReviewed
identifier:   Swedo, Susan E. and Pietrini, Pietro and Leonard, Henrietta L. and Schapiro, Mark B. and Rettew, David C. and Goldberger, Erica L. and Rapoport, Stanley I. and Rapoport, Judith L. and Grady, Cheryl L.  Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder: Revisualization during Pharmacotherapy.  Archives of General Psychiatry, 49 (9).  pp. 690-694.  ISSN 0003-990X      (1992)  
relation: http://archpsyc.jamanetwork.com/article.aspx?articleid=495863
relation: 10.1001/archpsyc.1992.01820090018003