eprintid: 3326
rev_number: 6
eprint_status: archive
userid: 69
dir: disk0/00/00/33/26
datestamp: 2016-03-23 13:41:20
lastmod: 2016-04-06 07:23:54
status_changed: 2016-03-23 13:41:20
type: article
metadata_visibility: show
creators_name: Swedo, Susan E.
creators_name: Pietrini, Pietro
creators_name: Leonard, Henrietta L.
creators_name: Schapiro, Mark B.
creators_name: Rettew, David C.
creators_name: Goldberger, Erica L.
creators_name: Rapoport, Stanley I.
creators_name: Rapoport, Judith L.
creators_name: Grady, Cheryl L.
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder: Revisualization during Pharmacotherapy
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
abstract: To investigate the effects of drug treatment in childhoodonset obsessive-compulsive disorder (OCD), we repeated positron emission tomographic scans in 13 adults with OCD (eight taking clomipramine, two taking fluoxetine, and three taking no drug) after at least 1 year of pharmacotherapy. As a group, the patients had a significant improvement on all OCD and anxiety ratings. Positron emission tomography revealed a significant decrease in normalized orbitofrontal regional cerebral glucose metabolism (relative to global metabolism) bilaterally. Among the treated patients, the decrease in right orbitofrontal metabolism was directly correlated with two measures of OCD improvement. These results extend previous positron emission tomographic findings of regional dysfunction in OCD and suggest involvement of the orbitofrontal regions in the pathophysiology of OCD.
date: 1992
date_type: published
publication: Archives of General Psychiatry
volume: 49
number: 9
publisher: American Medical Association
pagerange: 690-694
id_number: 10.1001/archpsyc.1992.01820090018003
refereed: TRUE
issn: 0003-990X
official_url: http://archpsyc.jamanetwork.com/article.aspx?articleid=495863
citation:   Swedo, Susan E. and Pietrini, Pietro and Leonard, Henrietta L. and Schapiro, Mark B. and Rettew, David C. and Goldberger, Erica L. and Rapoport, Stanley I. and Rapoport, Judith L. and Grady, Cheryl L.  Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder: Revisualization during Pharmacotherapy.  Archives of General Psychiatry, 49 (9).  pp. 690-694.  ISSN 0003-990X      (1992)