relation: http://eprints.imtlucca.it/3327/
title: Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease
creator: Schapiro, Mark B.
creator: Pietrini, Pietro
creator: Grady, Cheryl L.
creator: Ball, M.J.
creator: De Carli, Charles
creator: Kumar, Anand
creator: Kaye, Jeffrey A.
creator: Haxby, James V.
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: Reduction in the regional cerebral metabolic rate for glucose (rCMRglc) in the parietal and temporal regions has been shown in Alzheimer's disease (AD). The specificity of these findings for this disease state is uncertain. We repeatedly measured rCMRglc with positron emission tomography and 18F2-fluoro-2-deoxy-D-glucose in the resting state in a 68 year old man with slowly progressive dementia who, during life, was initially diagnosed as having dementia of the Alzheimer type, then Parkinson disease with dementia, but was found to have only Parkinson's disease at necropsy. Metabolic ratios (rCMRglc/mean grey CMRglc) were significantly (p <0 05) reduced in parietal and temporal regions, as well as in the prefrontal and premotor areas. This pattern was similar in regional distribution and magnitude of the defect to that seen in patients with probable AD. These results suggest that reductions of glucose metabolism in association neocortex in AD are not specific to the disease process, but may be related to the dementia state.
publisher: BMJ Publishing Group
date: 1993
type: Article
type: PeerReviewed
identifier:   Schapiro, Mark B. and Pietrini, Pietro and Grady, Cheryl L. and Ball, M.J. and De Carli, Charles and Kumar, Anand and Kaye, Jeffrey A. and Haxby, James V.  Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease.  Journal of Neurology, Neurosurgery and Psychiatry, 56 (8).  pp. 859-864.  ISSN 0022-3050      (1993)  
relation: http://jnnp.bmj.com/content/56/8/859
relation: 10.1136/jnnp.56.8.859